Vesicles modulate an actin network for asymmetric spindle positioning
نویسندگان
چکیده
منابع مشابه
Asymmetric spindle positioning.
When a spindle is positioned asymmetrically in a dividing cell, the resulting daughter cells are unequal in size. Asymmetric spindle positioning is driven by regulated forces that can pull or push a spindle. The physical and molecular mechanisms that can position spindles asymmetrically have been studied in several systems, and some themes have begun to emerge from recent research. Recent work ...
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Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to undergo BBSome-mediated retrieval from cilia back into the cell, these GPCRs concentrate into membranous buds at the tips of cilia before release into extracellular vesicles named ectosomes. Unexpectedly, actin and the a...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2013
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2802